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Helping develop safer vaccines for patients at risk

This project was completed in December 2011.  

The Atopic Dermatitis and Vaccinia Immunization Network (ADVN) sponsored by the National Institutes of Allergy and Infectious Diseases (NIAID) comprised a Clinical Studies Consortium, an Animal Studies Consortium, and a Statistical and Data Coordinating Center (SDCC). The primary goal of the ADVN was to advance clinical research in the development of safer smallpox vaccines for individuals with atopic dermatitis (AD). People with atopic dermatitis should not receive the smallpox immunization because of increased risk of a serious and potentially fatal complication called eczema vaccinatum. Data from this research will form the basis for new diagnostic and therapeutic approaches to reduce the prevalence of eczema vaccinatum following smallpox vaccination.

Rho served as the SDCC for the ADVN, providing support for the network’s clinical and animal study consortium. In this capacity, Rho was responsible for statistical and data analysis, clinical coordination, regulatory guidancecomputer-based data collection and managementoperational support, and the establishment and maintenance of a registry of patients with atopic dermatitis.

Gloria David, Ph.D., M.H.Sc., was Principal Investigator (PI) of the ADVN SDCC. As a post-doctoral fellow for both the Johns Hopkins Department of Oncology and the National Institute of Environmental Health Sciences, Dr. David received numerous professional honors for accomplishments in cancer research and respiratory disease. She is lead author in many peer-reviewed publications for research in lung, prostate, and breast cancer, asthma, and other respiratory diseases. Karen Kesler, Ph.D., Senior Statistical Scientist, was the co-PI for this research program.

For more information about this research from ClinicalTrials.gov, please see below.

ADVN Biomarker Registry Study

Immune Response to Yellow Fever Vaccination in Adults with Atopic Dermatitis

Identifying Risk Factors for Eczema Herpeticum in Individuals with Atopic Dermatitis (ADEH)

Responses to Immunization with Keyhole Limpet Hemocyanin Administered by Scarification and the Intradermal Route (KLH)

Identifying Genetic Determinants of Eczema Herpeticum and Other Viral Infections in Individuals With Atopic Dermatitis (Genetics)

Role of Antimicrobial Peptides in Host Defense Against Vaccinia Virus (AMP)

The Underlying Mechanisms for S. Aureus Infection and Colonization of Skin in People with Atopic Dermatitis with and without Eczema Herpeticum (MRSA)

Comparison of Cathelicidin Expression in Skin and Saliva in Patients with Atopic Dermatitis and Psoriasis

Analysis of Response of Subjects with Atopic Dermatitis or Psoriasis to Oral Vitamin D3

Immune Response to Varicella Vaccination in Children with Atopic Dermatitis