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BTRP & CTC

Helping discover curative therapies and improvements in treatments

The Basic and Translational Research Program (BTRP) for sickle cell disease is supported by the National Heart, Lung, and Blood Institute (NHLBI) to focus on “bench-to-bedside” research in sickle cell disease. Twenty research studies have been funded at 12 institutions. The BTRP program began in April 2008 and will continue through March 2012. Additionally, each institution will offer a Scholar Program to support a young investigator’s research in this field.

Clinical Trials Consortium

The Clinical Trials Consortium (CTC) for sickle cell disease is supported by NHLBI to complete four multicenter studies that began in the last funding cycle of the Comprehensive Sickle Cell Centers (CSCC) program. Approximately 30 sites are participating in at least one of these four trials. These studies include CHAMPS (Effectiveness of Hydroxyurea and Magnesium Pidolate Alone and in Combination in Hemoglobin SC Disease) and Neuropsych II (a Randomized Pilot Study of the Impact of Transfusion on Cognitive Function in Adults with SCD). 

As head of the statistical and data coordinating center for both of these networks, Rho provides operational and statistical leadership, protocol development, case report form development, site management, clinical monitoringclinical data management, data monitoring committee and steering committee support, progress and statistical reporting, and final clinical study report and manuscript preparationKaren Kesler (Ph.D., Assistant Director) is the principal investigator (PI) for these coordinating centers, and the study is sponsored by the NHLBI.

This program concluded in 2012.

For more information about this research from ClinicalTrials.gov, please see below.

Neuropsychological Dysfunction and Neuroimaging Abnormalities in Neurologically Intact Adult Patients with Sickle Cell Disease

Neuropsychological Dysfunction and Neuroimaging Abnormalities in Neurologically Intact Adult Patients with Sickle Cell Disease – Pilot Transfusion Phase

Effectiveness of Hydroxyurea and Magnesium Pidolate Alone and in Combination in Hemoglobin Sickle Cell Disease

Randomized Trial of Oral Dexamethasone for Acute Chest Syndrome

Establishing a Database of People With Sickle Cell Disease (Comprehensive Sickle Cell Centers Collaborative Data Project [C-Data]) C-Data DNA (Genotype-Phenotype)

Establishing a Repository of Blood and DNA Samples From People With Sickle Cell Disease (Comprehensive Sickle Cell Centers Collaborative Genotype-Phenotype Database and Sample Repository) (Gen/Phen)

Priapism in Boys and Men With Sickle Cell Disease - Demographics, Characteristics and Prevalence

Arginine Supplementation in Sickle Cell Anemia: Physiological and Prophylactic Effects