Dental Research and Clinical Trials

Rho has extensive experience with dental research and clinical trials

Our extensive experience conducting dental clinical trials includes over 135 dental studies working with nearly 400 sites and enrolling more than 50,000 subjects.Some advantages of working with Rho on your dental trial:

  • Experience in federally funded and commercially funded dental trials, including our role as the Clinical Research Operations and Management Support (CROMS) provider for the National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
  • Strong site relationships
  • On-staff dentist and dental hygienist
  • In-depth understanding of the unique challenges of dental trials, such as:
    • Managing the high volumes of dental samples typical of dental trials
    • Developing executable dental protocols based on knowledge of working practices in dental clinics
  • Experience using advanced statistical methods to:
    • Account for multiple levels of statistical correlation, such as correlations between surfaces on a tooth, teeth within a subject, and subjects within a clinic
    • Analyze measurements of dental disease repeated through time
    • Handle missing data cause by the loss of a tooth during a trial or the loss of a subject to follow-up
  • Extensive electronic data capture (EDC) experience in dental trials, including:
    • Designing electronic case report forms (eCRFs) that can accomodate the large number of data fields required for a periodontal examination
    • Designing systems that can make instantaneous calculations of changes in measures of periodontal disease from a previous examination and alert the examiner to significant changes


Dental Trial Problem Solving

A recent research trial required collection of more than 700,000 lab specimens.  To meet this need, we integrated RhoLAB, our proprietary laboratory tracking system, with Medidata’s RAVE EDC to automate the transfer of specimen tracking information between systems.  As a result, the project team was able to ensure accuracy in specimen tracking while simultaneously decreasing the impact handling so many specimens would have on clinical staff.

Rho has experience in a range of dental and craniofacial indications including:

  • Behavioral interventions
  • Craniosynostosis
  • Taste sensitivity
  • Periodontal surgery
  • Fluoride exposure
  • Oral mucositis
  • Cleft palate
  • Craniofacial microsomia
  • Dry mouth
  • Teeth whitening
  • Periodontal infections/gingivitis
  • Dental plaque
  • Oral irritation and sensitization
  • Dental caries
  • Oral wound healing
  • Temporomandibular disorder
  • Salivary gland dysfunction
  • Oral cancer
  • Sjögren's syndrome

Click the link below to learn more about Rho's dental experience in clinical research.