Publications List

Rho’s clinical research experts are some of the most respected and well published in the pharmaceutical, biotech, and medical device clinical research industry. The following is a list of publications from our world-class researchers.

Title Citation
Effects of omalizumab on T lymphocyte function in inner-city children with asthma Gruchalla RS, Sampson HA, Liu AH, Shreffler W, Wallace PK, Togias A, David G, Calatroni A, LeBeau P; Inner-city Asthma Consortium. Pediatr Allergy Immunol. 2016 May;27(3):328-31. doi: 10.1111/pai.12508. Epub 2016 Feb 18. PMID: 26573086; PMCID: PMC4888877.
Rhinitis in children and adolescents with asthma: Ubiquitous, difficult to control, and associated with asthma outcomes Togias A, Gergen PJ, Hu JW, Babineau DC, Wood RA, Cohen RT, Makhija MM, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Liu AH, Wang E, Kim H, Lamm CI, Bacharier LB, Pillai D, Sigelman SM, Gern JE, Busse WW. J Allergy Clin Immunol. 2019 Mar;143(3):1003-1011.e10. doi: 10.1016/j.jaci.2018.07.041. Epub 2018 Sep 11. PMID: 30213627; PMCID: PMC6408960.
Early-life home environment and risk of asthma among inner-city children O’Connor GT, Lynch SV, Bloomberg GR, Kattan M, Wood RA, Gergen PJ, Jaffee KF, Calatroni A, Bacharier LB, Beigelman A, Sandel MT, Johnson CC, Faruqi A, Santee C, Fujimura KE, Fadrosh D, Boushey H, Visness CM, Gern JE. J Allergy Clin Immunol. 2018 Apr;141(4):1468-1475. doi: 10.1016/j.jaci.2017.06.040. Epub 2017 Sep 19. PMID: 28939248; PMCID: PMC6521865.
Longitudinal Phenotypes of Respiratory Health in a High-Risk Urban Birth Cohort Bacharier LB, Beigelman A, Calatroni A, Jackson DJ, Gergen PJ, O’Connor GT, Kattan M, Wood RA, Sandel MT, Lynch SV, Fujimura KE, Fadrosh DW, Santee CA, Boushey H, Visness CM, Gern JE; NIAID sponsored Inner-City Asthma Consortium. Am J Respir Crit Care Med. 2019 Jan 1;199(1):71-82. doi: 10.1164/rccm.201801-0190OC. PMID: 30079758; PMCID: PMC6353010.
Allergen specificity of early peanut consumption and effect on development of allergic disease in the Learning Early About Peanut Allergy study cohort du Toit G, Sayre PH, Roberts G, Lawson K, Sever ML, Bahnson HT, Fisher HR, Feeney M, Radulovic S, Basting M, Plaut M, Lack G; Immune Tolerance Network Learning Early About Peanut Allergy study team. J Allergy Clin Immunol. 2018 Apr;141(4):1343-1353. doi: 10.1016/j.jaci.2017.09.034. Epub 2017 Oct 31. PMID: 29097103; PMCID: PMC5889963.
Impact of Past Research Experience on Subsequent Trials: A Caution Villarreal MA, Wildfire JJ, Sorkness CA, Gergen PJ, Visness CM, Mitchell HE. Am J Respir Crit Care Med. 2020 Jan 15;201(2):253-256. doi: 10.1164/rccm.201905-0926LE. PMID: 31525073; PMCID: PMC6961745.
Asthma phenotypes in inner-city children Zoratti EM, Krouse RZ, Babineau DC, Pongracic JA, O’Connor GT, Wood RA, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Kattan M, Teach SJ, Sigelman SM, Gergen PJ, Togias A, Visness CM, Busse WW, Liu AH. J Allergy Clin Immunol. 2016 Oct;138(4):1016-1029. doi: 10.1016/j.jaci.2016.06.061. PMID: 27720016; PMCID: PMC5104222.
Effect of 2 Years of Treatment With Sublingual Grass Pollen Immunotherapy on Nasal Response to Allergen Challenge at 3 Years Among Patients With Moderate to Severe Seasonal Allergic Rhinitis: The GRASS Randomized Clinical Trial Scadding GW, Calderon MA, Shamji MH, Eifan AO, Penagos M, Dumitru F, Sever ML, Bahnson HT, Lawson K, Harris KM, Plough AG, Panza JL, Qin T, Lim N, Tchao NK, Togias A, Durham SR; Immune Tolerance Network GRASS Study Team. JAMA. 2017 Feb 14;317(6):615-625. doi: 10.1001/jama.2016.21040. PMID: 28196255; PMCID: PMC5479315.
The nasal methylome and childhood atopic asthma Yang IV, Pedersen BS, Liu AH, O’Connor GT, Pillai D, Kattan M, Misiak RT, Gruchalla R, Szefler SJ, Khurana Hershey GK, Kercsmar C, Richards A, Stevens AD, Kolakowski CA, Makhija M, Sorkness CA, Krouse RZ, Visness C, Davidson EJ, Hennessy CE, Martin RJ, Togias A, Busse WW, Schwartz DA. J Allergy Clin Immunol. 2017 May;139(5):1478-1488. doi: 10.1016/j.jaci.2016.07.036. Epub 2016 Oct 13. PMID: 27745942; PMCID: PMC5391298.
Patients with Atopic Dermatitis Colonized with Staphylococcus aureus Have a Distinct Phenotype and Endotype Simpson EL, Villarreal M, Jepson B, Rafaels N, David G, Hanifin J, Taylor P, Boguniewicz M, Yoshida T, De Benedetto A, Barnes KC, Leung DYM, Beck LA. J Invest Dermatol. 2018 Oct;138(10):2224-2233. doi: 10.1016/j.jid.2018.03.1517. Epub 2018 Mar 28. PMID: 29604251; PMCID: PMC6153055.
Temporal and Racial Differences Associated with Atopic Dermatitis Staphylococcusaureus and Encoded Virulence Factors Merriman JA, Mueller EA, Cahill MP, Beck LA, Paller AS, Hanifin JM, Ong PY, Schneider L, Babineau DC, David G, Lockhart A, Artis K, Leung DY, Schlievert PM. mSphere. 2016 Dec 7;1(6):e00295-16. doi: 10.1128/mSphere.00295-16. eCollection 2016 Nov-Dec. PMID: 27981233; PMCID: PMC5143412.
Enhanced plasmacytoid dendritic cell antiviral responses after omalizumab Gill MA, Liu AH, Calatroni A, Krouse RZ, Shao B, Schiltz A, Gern JE, Togias A, Busse WW. J Allergy Clin Immunol. 2018 May;141(5):1735-1743.e9. doi: 10.1016/j.jaci.2017.07.035. Epub 2017 Sep 1. PMID: 28870461; PMCID: PMC6013066.
Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis Nakatsuji T, Chen TH, Narala S, Chun KA, Two AM, Yun T, Shafiq F, Kotol PF, Bouslimani A, Melnik AV, Latif H, Kim JN, Lockhart A, Artis K, David G, Taylor P, Streib J, Dorrestein PC, Grier A, Gill SR, Zengler K, Hata TR, Leung DY, Gallo RL. Sci Transl Med. 2017 Feb 22;9(378):eaah4680. doi: 10.1126/scitranslmed.aah4680. PMID: 28228596; PMCID: PMC5600545.
Obstruction phenotype as a predictor of asthma severity and instability in children Sorkness RL, Zoratti EM, Kattan M, Gergen PJ, Evans MD, Visness CM, Gill M, Khurana Hershey GK, Kercsmar CM, Liu AH, O’Connor GT, Pongracic JA, Pillai D, Sorkness CA, Togias A, Wood RA, Busse WW. J Allergy Clin Immunol. 2018 Oct;142(4):1090-1099.e4. doi: 10.1016/j.jaci.2017.09.047. Epub 2017 Nov 14. PMID: 29146272; PMCID: PMC5951738.
Altered composition of epidermal lipids correlates with Staphylococcus aureus colonization status in atopic dermatitis Li S, Villarreal M, Stewart S, Choi J, Ganguli-Indra G, Babineau DC, Philpot C, David G, Yoshida T, Boguniewicz M, Hanifin JM, Beck LA, Leung DY, Simpson EL, Indra AK. Br J Dermatol. 2017 Oct;177(4):e125-e127. doi: 10.1111/bjd.15409. Epub 2017 Sep 5. PMID: 28244066; PMCID: PMC5573657.
The influence of atopy and asthma on immune responses in inner-city adults Kakumanu S, Jaffee K, Visness CM, Dresen A, Burger M, Witter FR, O’Connor GT, Cruikshank WW, Shreffler WG, Bacharier LB, Gern JE. Immun Inflamm Dis. 2016 Feb 26;4(1):80-90. doi: 10.1002/iid3.96. eCollection 2016 Mar. PMID: 27042305; PMCID: PMC4768071.
Sensitization and Exposure to Pets: The Effect on Asthma Morbidity in the US Population Gergen PJ, Mitchell HE, Calatroni A, Sever ML, Cohn RD, Salo PM, Thorne PS, Zeldin DC. J Allergy Clin Immunol Pract. 2018 Jan-Feb;6(1):101-107.e2. doi: 10.1016/j.jaip.2017.05.019. Epub 2017 Jul 8. PMID: 28694047; PMCID: PMC5756688.
Replicated methylation changes associated with eczema herpeticum and allergic response Boorgula MP, Taub MA, Rafaels N, Daya M, Campbell M, Chavan S, Shetty A, Cheadle C, Barkataki S, Fan J, David G, Beaty TH, Ruczinski I, Hanifin J, Schneider LC, Gallo RL, Paller AS, Beck LA, Leung DY, Mathias RA, Barnes KC. Clin Epigenetics. 2019 Aug 23;11(1):122. doi: 10.1186/s13148-019-0714-1. PMID: 31443688; PMCID: PMC6706929.
A computerized decision support tool to implement asthma guidelines for children and adolescents Kercsmar CM, Sorkness CA, Calatroni A, Gergen PJ, Bloomberg GR, Gruchalla RS, Kattan M, Liu AH, O’Connor GT, Pongracic JA, Szefler SJ, Teach SJ, Wildfire JJ, Wood RA, Zoratti EM, Busse WW; National Institute of Allergy and Infectious Diseases–sponsored Inner-City Asthma Consortium. J Allergy Clin Immunol. 2019 May;143(5):1760-1768. doi: 10.1016/j.jaci.2018.10.060. Epub 2018 Dec 5. PMID: 30529451; PMCID: PMC6504600.
Distinguishing characteristics of difficult-to-control asthma in inner-city children and adolescents Pongracic JA, Krouse RZ, Babineau DC, Zoratti EM, Cohen RT, Wood RA, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Kattan M, Teach SJ, Johnson CC, Bacharier LB, Gern JE, Sigelman SM, Gergen PJ, Togias A, Visness CM, Busse WW, Liu AH. J Allergy Clin Immunol. 2016 Oct;138(4):1030-1041. doi: 10.1016/j.jaci.2016.06.059. PMID: 27720017; PMCID: PMC5379996.
Distinct nasal airway bacterial microbiotas differentially relate to exacerbation in pediatric patients with asthma McCauley K, Durack J, Valladares R, Fadrosh DW, Lin DL, Calatroni A, LeBeau PK, Tran HT, Fujimura KE, LaMere B, Merana G, Lynch K, Cohen RT, Pongracic J, Khurana Hershey GK, Kercsmar CM, Gill M, Liu AH, Kim H, Kattan M, Teach SJ, Togias A, Boushey HA, Gern JE, Jackson DJ, Lynch SV; National Institute of Allergy and Infectious Diseases–sponsored Inner-City Asthma Consortium. J Allergy Clin Immunol. 2019 Nov;144(5):1187-1197. doi: 10.1016/j.jaci.2019.05.035. Epub 2019 Jun 13. PMID: 31201890; PMCID: PMC6842413.
Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma Altman MC, Whalen E, Togias A, O’Connor GT, Bacharier LB, Bloomberg GR, Kattan M, Wood RA, Presnell S, LeBeau P, Jaffee K, Visness CM, Busse WW, Gern JE. J Allergy Clin Immunol. 2018 Dec;142(6):1856-1866. doi: 10.1016/j.jaci.2018.02.019. Epub 2018 Mar 5. PMID: 29518416; PMCID: PMC6123299.
Pathways through which asthma risk factors contribute to asthma severity in inner-city children Liu AH, Babineau DC, Krouse RZ, Zoratti EM, Pongracic JA, O’Connor GT, Wood RA, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Kattan M, Teach SJ, Makhija M, Pillai D, Lamm CI, Gern JE, Sigelman SM, Gergen PJ, Togias A, Visness CM, Busse WW. J Allergy Clin Immunol. 2016 Oct;138(4):1042-1050. doi: 10.1016/j.jaci.2016.06.060. PMID: 27720018; PMCID: PMC5381517.
Statistical Considerations of Food Allergy Prevention Studies Bahnson HT, du Toit G, Lack G. J Allergy Clin Immunol Pract. 2017 Mar-Apr;5(2):274-282. doi: 10.1016/j.jaip.2016.12.007. PMID: 28283152; PMCID: PMC5683073.
Letter of response to Greenhawt et al. ‘LEAPing Through the Looking Glass: Secondary Analysis of the Effect of Skin Test Size and Age of Introduction on Peanut Tolerance after Early Peanut Introduction’ Lawson K, Bahnson HT, Brittain E, Sever M, Du Toit G, Lack G, Keet C, Greenhawt M, Fleischer D, Chan ES, Venter C, Stukus D, Gupta R, Spergel J. Allergy. 2017 Aug;72(8):1267-1271. doi: 10.1111/all.13127. PMID: 28691223; PMCID: PMC5796413.
Bedroom allergen exposures in US households Salo PM, Wilkerson J, Rose KM, Cohn RD, Calatroni A, Mitchell HE, Sever ML, Gergen PJ, Thorne PS, Zeldin DC. J Allergy Clin Immunol. 2018 May;141(5):1870-1879.e14. doi: 10.1016/j.jaci.2017.08.033. Epub 2017 Nov 30. PMID: 29198587; PMCID: PMC5938098.
Impact of peanut consumption in the LEAP Study: Feasibility, growth, and nutrition Feeney M, Du Toit G, Roberts G, Sayre PH, Lawson K, Bahnson HT, Sever ML, Radulovic S, Plaut M, Lack G; Immune Tolerance Network LEAP Study Team. J Allergy Clin Immunol. 2016 Oct;138(4):1108-1118. doi: 10.1016/j.jaci.2016.04.016. Epub 2016 Jun 10. PMID: 27297994; PMCID: PMC5056823.
The association of allergic sensitization patterns in early childhood with disease manifestations and immunological reactivity at 10 years of age Schulten V, Frazier A, Calatroni A, Kattan M, Bacharier LB, O’Connor GT, Sandel MT, Wood RA, Wheatley LM, Togias A, Visness CM, Dresen A, Gern JE, Sette A. Clin Exp Allergy. 2019 Aug;49(8):1087-1094. doi: 10.1111/cea.13406. Epub 2019 May 29. PMID: 31046157; PMCID: PMC6896992.
Effects of Omalizumab on Rhinovirus Infections, Illnesses, and Exacerbations of Asthma Esquivel A, Busse WW, Calatroni A, Togias AG, Grindle KG, Bochkov YA, Gruchalla RS, Kattan M, Kercsmar CM, Khurana Hershey G, Kim H, Lebeau P, Liu AH, Szefler SJ, Teach SJ, West JB, Wildfire J, Pongracic JA, Gern JE. Am J Respir Crit Care Med. 2017 Oct 15;196(8):985-992. doi: 10.1164/rccm.201701-0120OC. PMID: 28608756; PMCID: PMC5649984.
Screen Time Engagement Is Increased in Urban Children With Asthma Rota AP, Bacharier LB, Jaffee K, Visness CM, Kattan M, O’Connor GT, Wood RA, Gergen PJ, Gern JE, Bloomberg GR. Clin Pediatr (Phila). 2017 Oct;56(11):1048-1053. doi: 10.1177/0009922817698801. Epub 2017 Mar 20. PMID: 28871879; PMCID: PMC6378875.
A clinical trial of intradermal and intramuscular seasonal influenza vaccination in patients with atopic dermatitis Leung DYM, Jepson B, Beck LA, Hanifin JM, Schneider LC, Paller AS, Monti K, David G, Canniff J, Lorenzo MG, Weinberg A. J Allergy Clin Immunol. 2017 May;139(5):1575-1582.e8. doi: 10.1016/j.jaci.2016.12.952. Epub 2017 Feb 13. PMID: 28209343; PMCID: PMC5786280.
Relationships among Maternal Stress and Depression, Type 2 Responses, and Recurrent Wheezing at Age 3 Years in Low-Income Urban Families Ramratnam SK, Visness CM, Jaffee KF, Bloomberg GR, Kattan M, Sandel MT, Wood RA, Gern JE, Wright RJ. Am J Respir Crit Care Med. 2017 Mar 1;195(5):674-681. doi: 10.1164/rccm.201602-0272OC. PMID: 27654103; PMCID: PMC5363974.
Spirometry and Impulse Oscillometry in Preschool Children: Acceptability and Relationship to Maternal Smoking in Pregnancy Kattan M, Bacharier LB, O’Connor GT, Cohen R, Sorkness RL, Morgan W, Gergen PJ, Jaffee KF, Visness CM, Wood RA, Bloomberg GR, Doyle S, Burton R, Gern JE. J Allergy Clin Immunol Pract. 2018 Sep-Oct;6(5):1596-1603.e6. doi: 10.1016/j.jaip.2017.12.028. Epub 2018 Feb 13. PMID: 29449165; PMCID: PMC6089669.
Patterns of immune development in urban preschoolers with recurrent wheeze and/or atopy Gern JE, Calatroni A, Jaffee KF, Lynn H, Dresen A, Cruikshank WW, Lederman HM, Sampson HA, Shreffler W, Bacharier LB, Gergen PJ, Gold DR, Kattan M, O’Connor GT, Sandel MT, Wood RA, Bloomberg GR. J Allergy Clin Immunol. 2017 Sep;140(3):836-844.e7. doi: 10.1016/j.jaci.2016.10.052. Epub 2017 Jan 13. PMID: 28089873; PMCID: PMC5509531.
Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children Altman MC, Gill MA, Whalen E, Babineau DC, Shao B, Liu AH, Jepson B, Gruchalla RS, O’Connor GT, Pongracic JA, Kercsmar CM, Khurana Hershey GK, Zoratti EM, Johnson CC, Teach SJ, Kattan M, Bacharier LB, Beigelman A, Sigelman SM, Presnell S, Gern JE, Gergen PJ, Wheatley LM, Togias A, Busse WW, Jackson DJ. Version 2. Nat Immunol. 2019 May;20(5):637-651. doi: 10.1038/s41590-019-0347-8. Epub 2019 Apr 8. PMID: 30962590; PMCID: PMC6472965.
Endotypes of difficult-to-control asthma in inner-city African American children Brown KR, Krouse RZ, Calatroni A, Visness CM, Sivaprasad U, Kercsmar CM, Matsui EC, West JB, Makhija MM, Gill MA, Kim H, Kattan M, Pillai D, Gern JE, Busse WW, Togias A, Liu AH, Khurana Hershey GK. PLoS One. 2017 Jul 7;12(7):e0180778. doi: 10.1371/journal.pone.0180778. eCollection 2017. PMID: 28686637; PMCID: PMC5501607.
Can we predict fall asthma exacerbations? Validation of the seasonal asthma exacerbation index Hoch HE, Calatroni A, West JB, Liu AH, Gergen PJ, Gruchalla RS, Khurana Hershey GK, Kercsmar CM, Kim H, Lamm CI, Makhija MM, Mitchell HE, Teach SJ, Wildfire JJ, Busse WW, Szefler SJ. J Allergy Clin Immunol. 2017 Oct;140(4):1130-1137.e5. doi: 10.1016/j.jaci.2017.01.026. Epub 2017 Feb 24. PMID: 28238748; PMCID: PMC5568982.
Minimally important differences and risk levels for the Composite Asthma Severity Index Krouse RZ, Sorkness CA, Wildfire JJ, Calatroni A, Gruchalla R, Hershey GKK, Kattan M, Liu AH, Makhija M, Teach SJ, West JB, Wood RA, Zoratti EM, Gergen PJ. J Allergy Clin Immunol. 2017 Mar;139(3):1052-1055. doi: 10.1016/j.jaci.2016.08.041. Epub 2016 Oct 12. PMID: 27744028; PMCID: PMC5342920.
ACCLAIM: A randomized trial of abatacept (CTLA4-Ig) for relapsing-remitting multiple sclerosis Khoury SJ, Rochon J, Ding L, Byron M, Ryker K, Tosta P, Gao W, Freedman MS, Arnold DL, Sayre PH, Smilek DE; ACCLAIM Study Group. Mult Scler. 2017 Apr;23(5):686-695. doi: 10.1177/1352458516662727. Epub 2016 Aug 5. PMID: 27481207; PMCID: PMC5288398.
Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma Sullivan KM, Goldmuntz EA, Keyes-Elstein L, McSweeney PA, Pinckney A, Welch B, Mayes MD, Nash RA, Crofford LJ, Eggleston B, Castina S, Griffith LM, Goldstein JS, Wallace D, Craciunescu O, Khanna D, Folz RJ, Goldin J, St Clair EW, Seibold JR, Phillips K, Mineishi S, Simms RW, Ballen K, Wener MH, Georges GE, Heimfeld S, Hosing C, Forman S, Kafaja S, Silver RM, Griffing L, Storek J, LeClercq S, Brasington R, Csuka ME, Bredeson C, Keever-Taylor C, Domsic RT, Kahaleh MB, Medsger T, Furst DE; SCOT Study Investigators. N Engl J Med. 2018 Jan 4;378(1):35-47. doi: 10.1056/nejmoa1703327. PMID: 29298160; PMCID: PMC5846574.
Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial Gitelman SE, Gottlieb PA, Felner EI, Willi SM, Fisher LK, Moran A, Gottschalk M, Moore WV, Pinckney A, Keyes-Elstein L, Harris KM, Kanaparthi S, Phippard D, Ding L, Bluestone JA, Ehlers MR; ITN START Study Team. Diabetologia. 2016 Jun;59(6):1153-61. doi: 10.1007/s00125-016-3917-4. Epub 2016 Apr 6. PMID: 27053235; PMCID: PMC4869699.
Myeloablation followed by autologous stem cell transplantation normalises systemic sclerosis molecular signatures Assassi S, Wang X, Chen G, Goldmuntz E, Keyes-Elstein L, Ying J, Wallace PK, Turner J, Zheng WJ, Pascual V, Varga J, Hinchcliff ME, Bellocchi C, McSweeney P, Furst DE, Nash RA, Crofford LJ, Welch B, Pinckney A, Mayes MD, Sullivan KM. Ann Rheum Dis. 2019 Oct;78(10):1371-1378. doi: 10.1136/annrheumdis-2019-215770. Epub 2019 Aug 7. PMID: 31391177; PMCID: PMC7167108.
Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients Rigby MR, Harris KM, Pinckney A, DiMeglio LA, Rendell MS, Felner EI, Dostou JM, Gitelman SE, Griffin KJ, Tsalikian E, Gottlieb PA, Greenbaum CJ, Sherry NA, Moore WV, Monzavi R, Willi SM, Raskin P, Keyes-Elstein L, Long SA, Kanaparthi S, Lim N, Phippard D, Soppe CL, Fitzgibbon ML, McNamara J, Nepom GT, Ehlers MR. J Clin Invest. 2015 Aug 3;125(8):3285-96. doi: 10.1172/JCI81722. Epub 2015 Jul 20. PMID: 26193635; PMCID: PMC4623571.
Alpha-1 antitrypsin treatment of new-onset type 1 diabetes: An open-label, phase I clinical trial (RETAIN) to assess safety and pharmacokinetics Weir GC, Ehlers MR, Harris KM, Kanaparthi S, Long A, Phippard D, Weiner LJ, Jepson B, McNamara JG, Koulmanda M, Strom TB; ITN RETAIN Study Team. Pediatr Diabetes. 2018 Aug;19(5):945-954. doi: 10.1111/pedi.12660. Epub 2018 May 7. PMID: 29473705; PMCID: PMC6030471.
Randomized, Double-Blind, Placebo-Controlled Trial of the Effect of Vitamin D3 on the Interferon Signature in Patients With Systemic Lupus Erythematosus Aranow C, Kamen DL, Dall’Era M, Massarotti EM, Mackay MC, Koumpouras F, Coca A, Chatham WW, Clowse ME, Criscione-Schreiber LG, Callahan S, Goldmuntz EA, Keyes-Elstein L, Oswald M, Gregersen PK, Diamond B. Arthritis Rheumatol. 2015 Jul;67(7):1848-57. doi: 10.1002/art.39108. PMID: 25777546; PMCID: PMC4732716.
Clinical Efficacy and Safety of Baminercept, a Lymphotoxin β Receptor Fusion Protein, in Primary Sjögren’s Syndrome: Results From a Phase II Randomized, Double-Blind, Placebo-Controlled Trial St Clair EW, Baer AN, Wei C, Noaiseh G, Parke A, Coca A, Utset TO, Genovese MC, Wallace DJ, McNamara J, Boyle K, Keyes-Elstein L, Browning JL, Franchimont N, Smith K, Guthridge JM, Sanz I, James JA; Autoimmunity Centers of Excellence. Arthritis Rheumatol. 2018 Sep;70(9):1470-1480. doi: 10.1002/art.40513. Epub 2018 Jul 18. PMID: 29604186; PMCID: PMC6115299.
Short-term progression of interstitial lung disease in systemic sclerosis predicts long-term survival in two independent clinical trial cohorts Volkmann ER, Tashkin DP, Sim M, Li N, Goldmuntz E, Keyes-Elstein L, Pinckney A, Furst DE, Clements PJ, Khanna D, Steen V, Schraufnagel DE, Arami S, Hsu V, Roth MD, Elashoff RM, Sullivan KM; SLS I and SLS II study groups. Ann Rheum Dis. 2019 Jan;78(1):122-130. doi: 10.1136/annrheumdis-2018-213708. Epub 2018 Nov 8. PMID: 30409830; PMCID: PMC6311344.
Manufacture of Autologous CD34(+) Selected Grafts in the NIAID-Sponsored HALT-MS and SCOT Multicenter Clinical Trials for Autoimmune Diseases Keever-Taylor CA, Heimfeld S, Steinmiller KC, Nash RA, Sullivan KM, Czarniecki CW, Granderson TC, Goldstein JS, Griffith LM. Biol Blood Marrow Transplant. 2017 Sep;23(9):1463-1472. doi: 10.1016/j.bbmt.2017.05.018. Epub 2017 Jun 30. PMID: 28602891; PMCID: PMC5761325.
Two- and Four-Hour Tests Differ in Capture of C-Peptide Responses to a Mixed Meal in Type 1 Diabetes Boyle KD, Keyes-Elstein L, Ehlers MR, McNamara J, Rigby MR, Gitelman SE, Weiner LJ, Much KL, Herold KC. Diabetes Care. 2016 Jun;39(6):e76-8. doi: 10.2337/dc15-2077. Epub 2016 Apr 13. PMID: 27208317; PMCID: PMC4878222.
Correlation Among Hypoglycemia, Glycemic Variability, and C-Peptide Preservation After Alefacept Therapy in Patients with Type 1 Diabetes Mellitus: Analysis of Data from the Immune Tolerance Network T1DAL Trial Pinckney A, Rigby MR, Keyes-Elstein L, Soppe CL, Nepom GT, Ehlers MR. Clin Ther. 2016 Jun;38(6):1327-1339. doi: 10.1016/j.clinthera.2016.04.032. Epub 2016 May 18. PMID: 27209482; PMCID: PMC4916002.
High-dose immunosuppressive therapy and autologous HCT for relapsing-remitting MS Nash RA, Hutton GJ, Racke MK, Popat U, Devine SM, Steinmiller KC, Griffith LM, Muraro PA, Openshaw H, Sayre PH, Stuve O, Arnold DL, Wener MH, Georges GE, Wundes A, Kraft GH, Bowen JD. Neurology. 2017 Feb 28;88(9):842-852. doi: 10.1212/WNL.0000000000003660. Epub 2017 Feb 1. PMID: 28148635; PMCID: PMC5331868.
The Safety Explorer Suite: Interactive Safety Monitoring for Clinical Trials Wildfire J, Bailey R, Krouse RZ, Childress S, Sikora B, Bryant N, Rosanbalm S, Wilson E, Modell JG. Ther Innov Regul Sci. 2018 Nov;52(6):696-700. doi: 10.1177/2168479018754846. Epub 2018 Feb 5. PMID: 29714563; PMCID: PMC6026568.
Asthma as an outcome: Exploring multiple definitions of asthma across birth cohorts in the Environmental influences on Child Health Outcomes Children’s Respiratory and Environmental Workgroup Visness CM, Gebretsadik T, Jackson DJ, Biagini Myers J, Havstad S, Lemanske RF Jr, Hartert TV, Khurana Hershey GK, Zoratti EM, Martin LJ, Miller R, Gold DR, Wright A, Stern DA, Gern JE, Johnson CC; Children’s Respiratory and Environmental Workgroup. J Allergy Clin Immunol. 2019 Sep;144(3):866-869.e4. doi: 10.1016/j.jaci.2019.05.025. Epub 2019 Jun 1. PMID: 31163174; PMCID: PMC6742528.
The Children’s Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population Gern JE, Jackson DJ, Lemanske RF Jr, Seroogy CM, Tachinardi U, Craven M, Hwang SY, Hamilton CM, Huggins W, O’Connor GT, Gold DR, Miller R, Kattan M, Johnson CC, Ownby D, Zoratti EM, Wood RA, Visness CM, Martinez F, Wright A, Lynch S, Ober C, Khurana Hershey GK, Ryan P, Hartert T, Bacharier LB. Respir Res. 2019 Jun 10;20(1):115. doi: 10.1186/s12931-019-1088-9. PMID: 31182091; PMCID: PMC6558735.
Interferon Gamma ELISPOT Testing as a Risk-Stratifying Biomarker for Kidney Transplant Injury: Results From the CTOT-01 Multicenter Study Hricik DE, Augustine J, Nickerson P, Formica RN, Poggio ED, Rush D, Newell KA, Goebel J, Gibson IW, Fairchild RL, Spain K, Iklé D, Bridges ND, Heeger PS; CTOT-01 consortium. Am J Transplant. 2015 Dec;15(12):3166-73. doi: 10.1111/ajt.13401. Epub 2015 Jul 30. PMID: 26226830; PMCID: PMC4946339.
Early immune biomarkers and intermediate-term outcomes after heart transplantation: Results of Clinical Trials in Organ Transplantation-18 Stehlik J, Armstrong B, Baran DA, Bridges ND, Chandraker A, Gordon R, De Marco T, Givertz MM, Heroux A, Iklé D, Hunt J, Kfoury AG, Madsen JC, Morrison Y, Feller E, Pinney S, Tripathi S, Heeger PS, Starling RC. Am J Transplant. 2019 May;19(5):1518-1528. doi: 10.1111/ajt.15218. Epub 2019 Jan 22. PMID: 30549425; PMCID: PMC6482086.
Analysis of 75 Candidate SNPs Associated With Acute Rejection in Kidney Transplant Recipients: Validation of rs2910164 in MicroRNA MIR146A Oetting WS, Schladt DP, Dorr CR, Wu B, Guan W, Remmel RP, Iklé D, Mannon RB, Matas AJ, Israni AK, Jacobson PA; DeKAF Genomics and GEN03 Investigators. Transplantation. 2019 Aug;103(8):1591-1602. doi: 10.1097/TP.0000000000002659. PMID: 30801535; PMCID: PMC6913779.
Urine Metabolite Profiles Predictive of Human Kidney Allograft Status Suhre K, Schwartz JE, Sharma VK, Chen Q, Lee JR, Muthukumar T, Dadhania DM, Ding R, Ikle DN, Bridges ND, Williams NM, Kastenmüller G, Karoly ED, Mohney RP, Abecassis M, Friedewald J, Knechtle SJ, Becker YT, Samstein B, Shaked A, Gross SS, Suthanthiran M. J Am Soc Nephrol. 2016 Feb;27(2):626-36. doi: 10.1681/ASN.2015010107. Epub 2015 Jun 5. PMID: 26047788; PMCID: PMC4731125.
Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type Unizony S, Villarreal M, Miloslavsky EM, Lu N, Merkel PA, Spiera R, Seo P, Langford CA, Hoffman GS, Kallenberg CM, St Clair EW, Ikle D, Tchao NK, Ding L, Brunetta P, Choi HK, Monach PA, Fervenza F, Stone JH, Specks U; RAVE-ITN Research Group. Ann Rheum Dis. 2016 Jun;75(6):1166-9. doi: 10.1136/annrheumdis-2015-208073. Epub 2015 Nov 30. PMID: 26621483; PMCID: PMC4908815.
Study rationale, design, and pretransplantation alloantibody status: A first report of Clinical Trials in Organ Transplantation in Children-04 (CTOTC-04) in pediatric heart transplantation Zuckerman WA, Zeevi A, Mason KL, Feingold B, Bentlejewski C, Addonizio LJ, Blume ED, Canter CE, Dipchand AI, Hsu DT, Shaddy RE, Mahle WT, Demetris AJ, Briscoe DM, Mohanakumar T, Ahearn JM, Iklé DN, Armstrong BD, Morrison Y, Diop H, Odim J, Webber SA. Am J Transplant. 2018 Sep;18(9):2135-2147. doi: 10.1111/ajt.14695. Epub 2018 Mar 23. PMID: 29446208; PMCID: PMC6093810.
Development and clinical validity of a novel blood-based molecular biomarker for subclinical acute rejection following kidney transplant Friedewald JJ, Kurian SM, Heilman RL, Whisenant TC, Poggio ED, Marsh C, Baliga P, Odim J, Brown MM, Ikle DN, Armstrong BD, Charette JI, Brietigam SS, Sustento-Reodica N, Zhao L, Kandpal M, Salomon DR, Abecassis MM; Clinical Trials in Organ Transplantation 08 (CTOT-08). Am J Transplant. 2019 Jan;19(1):98-109. doi: 10.1111/ajt.15011. Epub 2018 Aug 31. PMID: 29985559; PMCID: PMC6387870.
Lessons Learned: Early Termination of a Randomized Trial of Calcineurin Inhibitor and Corticosteroid Avoidance Using Belatacept Newell KA, Mehta AK, Larsen CP, Stock PG, Farris AB, Mehta SG, Ikle D, Armstrong B, Morrison Y, Bridges N, Robien M, Mannon RB. Am J Transplant. 2017 Oct;17(10):2712-2719. doi: 10.1111/ajt.14377. Epub 2017 Jul 3. PMID: 28556519; PMCID: PMC5623170.
Epstein-Barr viral loads do not predict post-transplant lymphoproliferative disorder in pediatric lung transplant recipients: A multicenter prospective cohort study Parrish A, Fenchel M, Storch GA, Buller R, Mason S, Williams N, Ikle D, Conrad C, Faro A, Goldfarb S, Hayes D Jr, Melicoff-Portillo E, Schecter M, Visner G, Sweet S, Danziger-Isakov L; Clinical Trials in Organ Transplantation in Children (CTOTC-03). Pediatr Transplant. 2017 Sep;21(6):10.1111/petr.13011. doi: 10.1111/petr.13011. Epub 2017 Jun 21. PMID: 28639398; PMCID: PMC5568922.
Incidence, characterization, and impact of newly detected donor-specific anti-HLA antibody in the first year after pediatric heart transplantation: A report from the CTOTC-04 study Dipchand AI, Webber S, Mason K, Feingold B, Bentlejewski C, Mahle WT, Shaddy R, Canter C, Blume ED, Lamour J, Zuckerman W, Diop H, Morrison Y, Armstrong B, Ikle D, Odim J, Zeevi A; CTOTC-04 Investigators. Am J Transplant. 2018 Sep;18(9):2163-2174. doi: 10.1111/ajt.14691. Epub 2018 Mar 24. PMID: 29442424; PMCID: PMC6092243.
Relationship Among Viremia/Viral Infection, Alloimmunity, and Nutritional Parameters in the First Year After Pediatric Kidney Transplantation Ettenger R, Chin H, Kesler K, Bridges N, Grimm P, Reed EF, Sarwal M, Sibley R, Tsai E, Warshaw B, Kirk AD. Am J Transplant. 2017 Jun;17(6):1549-1562. doi: 10.1111/ajt.14169. Epub 2017 Feb 1. PMID: 27989013; PMCID: PMC5445007.
Adverse Outcomes of Tacrolimus Withdrawal in Immune-Quiescent Kidney Transplant Recipients Hricik DE, Formica RN, Nickerson P, Rush D, Fairchild RL, Poggio ED, Gibson IW, Wiebe C, Tinckam K, Bunnapradist S, Samaniego-Picota M, Brennan DC, Schröppel B, Gaber O, Armstrong B, Ikle D, Diop H, Bridges ND, Heeger PS; Clinical Trials in Organ Transplantation-09 Consortium. J Am Soc Nephrol. 2015 Dec;26(12):3114-22. doi: 10.1681/ASN.2014121234. Epub 2015 Apr 29. PMID: 25925687; PMCID: PMC4657844.
Five-year histological and serological follow-up of operationally tolerant pediatric liver transplant recipients enrolled in WISP-R Feng S, Demetris AJ, Spain KM, Kanaparthi S, Burrell BE, Ekong UD, Alonso EM, Rosenthal P, Turka LA, Ikle D, Tchao NK. Hepatology. 2017 Feb;65(2):647-660. doi: 10.1002/hep.28681. Epub 2016 Jul 27. PMID: 27302659; PMCID: PMC5159322.
Genetic Variants Associated With Immunosuppressant Pharmacokinetics and Adverse Effects in the DeKAF Genomics Genome-wide Association Studies Oetting WS, Wu B, Schladt DP, Guan W, van Setten J, Keating BJ, Iklé D, Remmel RP, Dorr CR, Mannon RB, Matas AJ, Israni AK, Jacobson PA; DeKAF Genomics and GEN-03 Investigators. Transplantation. 2019 Jun;103(6):1131-1139. doi: 10.1097/TP.0000000000002625. PMID: 30801552; PMCID: PMC6597284.
Multicenter Analysis of Immune Biomarkers and Heart Transplant Outcomes: Results of the Clinical Trials in Organ Transplantation-05 Study Starling RC, Stehlik J, Baran DA, Armstrong B, Stone JR, Ikle D, Morrison Y, Bridges ND, Putheti P, Strom TB, Bhasin M, Guleria I, Chandraker A, Sayegh M, Daly KP, Briscoe DM, Heeger PS; CTOT-05 consortium. Am J Transplant. 2016 Jan;16(1):121-36. doi: 10.1111/ajt.13422. Epub 2015 Aug 10. PMID: 26260101; PMCID: PMC4948061.
Absence of evidence that respiratory viral infections influence pediatric lung transplantation outcomes: Results of the CTOTC-03 study Sweet SC, Chin H, Conrad C, Hayes D Jr, Heeger PS, Faro A, Goldfarb S, Melicoff-Portillo E, Mohanakumar T, Odim J, Schecter M, Storch GA, Visner G, Williams NM, Kesler K, Danziger-Isakov L. Am J Transplant. 2019 Dec;19(12):3284-3298. doi: 10.1111/ajt.15505. Epub 2019 Jul 25. PMID: 31216376; PMCID: PMC6883118.
Perceived barriers to medication adherence remain stable following solid organ transplantation Danziger-Isakov L, Frazier TW, Worley S, Williams N, Shellmer D, Dharnidharka VR, Gupta NA, Ikle D, Shemesh E, Sweet SC; CTOTC-05 Consortium. Pediatr Transplant. 2019 May;23(3):e13361. doi: 10.1111/petr.13361. Epub 2019 Feb 12. PMID: 31332928; PMCID: PMC6652201.
Perceived barriers to medication adherence in pediatric and adolescent solid organ transplantation Danziger-Isakov L, Frazier TW, Worley S, Williams N, Shellmer D, Dharnidharka VR, Gupta NA, Ikle D, Sweet SC; CTOTC-05 Consortium. Pediatr Transplant. 2016 Mar;20(2):307-15. doi: 10.1111/petr.12648. Epub 2015 Dec 16. PMID: 26670870; PMCID: PMC6422022.
Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients Javaheri A, Molina M, Zamani P, Rodrigues A, Novak E, Chambers S, Stutman P, Maslanek W, Williams M, Lilly SM, Heeger P, Sayegh MH, Chandraker A, Briscoe DM, Daly KP, Starling R, Ikle D, Christie J, Rame JE, Goldberg LR, Billheimer J, Rader DJ. J Heart Lung Transplant. 2016 Nov;35(11):1295-1302. doi: 10.1016/j.healun.2016.06.022. Epub 2016 Jul 15. PMID: 27498384; PMCID: PMC5107129.
The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population Stapleton CP, Heinzel A, Guan W, van der Most PJ, van Setten J, Lord GM, Keating BJ, Israni AK, de Borst MH, Bakker SJL, Snieder H, Weale ME, Delaney F, Hernandez-Fuentes MP, Reindl-Schwaighofer R, Oberbauer R, Jacobson PA, Mark PB, Chapman FA, Phelan PJ, Kennedy C, Sexton D, Murray S, Jardine A, Traynor JP, McKnight AJ, Maxwell AP, Smyth LJ, Oetting WS, Matas AJ, Mannon RB, Schladt DP, Iklé DN, Cavalleri GL, Conlon PJ; UK Ireland Renal Transplant Consortium; DeKAF Genomics and GEN03 Studies; International Genetics and Translational Research in Transplantation Network. Am J Transplant. 2019 Aug;19(8):2262-2273. doi: 10.1111/ajt.15326. Epub 2019 Mar 28. PMID: 30920136; PMCID: PMC6989089.
Outcomes of immunosuppression minimization and withdrawal early after liver transplantation Shaked A, DesMarais MR, Kopetskie H, Feng S, Punch JD, Levitsky J, Reyes J, Klintmalm GB, Demetris AJ, Burrell BE, Priore A, Bridges ND, Sayre PH. Am J Transplant. 2019 May;19(5):1397-1409. doi: 10.1111/ajt.15205. Epub 2018 Dec 31. PMID: 30506630; PMCID: PMC6482056.
Tacrolimus troughs and genetic determinants of metabolism in kidney transplant recipients: A comparison of four ancestry groups Mohamed ME, Schladt DP, Guan W, Wu B, van Setten J, Keating BJ, Iklé D, Remmel RP, Dorr CR, Mannon RB, Matas AJ, Israni AK, Oetting WS, Jacobson PA; DeKAF Genomics and GEN03 Investigators. Am J Transplant. 2019 Oct;19(10):2795-2804. doi: 10.1111/ajt.15385. Epub 2019 May 13. PMID: 30953600; PMCID: PMC6763344.